Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases
نویسندگان
چکیده
منابع مشابه
Bile Acid Metabolism in Liver Diseases
For a long time, it has been assumed that the liver plays an important role in the formation and excretion of bile acids and that the metabolism of bile acids, therefore, can be disturbed to some extent in liver diseases. Pathophysiological aspects of the disturbed metabolism of bile acids remained obscure at the time when procedures of qualitative and quantitative analTses, identification and ...
متن کاملBile Acid Signaling in Liver Metabolism and Diseases
Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide. Overnutrition and insulin resistance are the major causes of diabetic hyperglycemia and hyperlipidemia in humans. Studies in the past decade provide evidence that bile acids are not just biological detergents facilitating gut nutrient absorption, but also important metabolic regulators of glucos...
متن کاملBile acid nuclear receptor FXR and digestive system diseases
Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, barrier f...
متن کاملHyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists
Bile acids are extensively investigated for their potential in the treatment of human disorders. The liver X receptors (LXRs), activated by oxysterols and by a secondary bile acid named hyodeoxycholic acid (HDCA), have been found essential in the regulation of lipid homeostasis in mammals. Unfortunately, LXRα activates lipogenic enzymes causing accumulation of lipid in the liver. In addition to...
متن کاملChronic Kidney Diseases and Nanoparticle Therapeutics
Present review article describes main causes of chronic kidney disease a major health problem public health problem round the globe. Disease has multiple etiologies related to sequential pathophysiological stages. It has major concern with chronic changes in renal structure and that severely alter glomerular filtration rate in patients. This article explains CKD biomarkers in brief i.e., serum ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Medicine
سال: 2020
ISSN: 2296-858X
DOI: 10.3389/fmed.2020.00015